Here are some of my favorites
Peter: Excuse me, is your refrigerator running? Because if it is, it probably runs like you.... very homosexually.
Peter: I'm gonna go microwave a bagel and have sex with it.
Quagmire: Butter's in the fridge!
Lois: Good, I don't have to cook.
Peter: Oh, no, go ahead and cook anyway, Lois, and we'll throw it out. I don't want you to get rusty.
Peter: I got an idea, an idea so smart my head would explode if I even began to know what I was talking about.
Peter: Lois, everyone has their sanctuary. The Catholics have churches, fat people have Wisconsin, and I have the Pawtucket Brewery.
Lois: Oh, I haven't been on a college campus in years. Everything seems so different.
Stewie: Really? Perhaps if you laid on your back with your ankles behind your ears that would ring a few bells.
Jewish Kid: Is anyone else having problems concentrating on this? I just can't seem to concentrate.
Cartman: Maybe we should send you to a concentration camp.
Kyle: Wow! That's a lot of seamen, Cartman.
Cartman: Yeah, I bought all that I could at this bank, and then I got the rest from this guy Ralph in an alley.
Stan: That's cool.
Cartman: Yeah, and the sweet thing is, the stupid ******* didn't even charge me money for it. He just made me close my eyes and suck on a hose.
Cartman: It's a man's obligation to stick his boneration in a women's separation; this sort of penetration will increase the population of the younger generation.
Cartman: Maury, I am out of control. Yeah, I use drugs. I can do what I waunt, biatch! Yeah, I have sex, and I don't use protection! It's my hot body; I'll do what I waunt! I don't go to school and I kill people! What-evah! I'll do what I waunt!
what is/are your favorite(s)